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The PFL 8 mixed martial arts event for the 2021 season of the Professional Fighters League was held on August 19, 2021. This was the second event for of the playoffs with the Heavyweight and Women's Lightweight divisions competing. This event aired on ESPN, with the prelims on ESPN+. Kayla Harrison, the only two-time Olympic gold medalist in judo in the history of the United States, entered her second PFL playoffs unbeaten in 10 pro bouts. She faced Genah Fabian who held a 4-1 record and had won both of her PFL regular season bouts against Julija Pajic and Laura Sanchez to advance to the playoffs.
Kayla Harrison
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Genah Fabian
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Bruno Cappelozza
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Jamelle Jones
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Taylor Guardado
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Mariana Morais
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Ante Delija
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Denis Goltsov
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Renan Ferreira
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Stuart Austin
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Muhammed DeReese
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Carl Seumanutafa
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Marina Mokhnatkina
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Claudia Zamora
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Amanda Leve
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Miranda Barber
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Christian Lohsen
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Jonas Flok
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