Leonardo DiCaprio
Dr. Randall Mindy
Jennifer Lawrence
Kate Dibiasky
Meryl Streep
President Orlean
Cate Blanchett
Brie Evantee
Rob Morgan
Dr. Teddy Oglethorpe
Jonah Hill
Jason Orlean
Mark Rylance
Peter Isherwell
Tyler Perry
Jack Bremmer
Timothée Chalamet
Yule
Ron Perlman
Benedict Drask
Ariana Grande
Riley Bina
Kid Cudi
DJ Chello
Himesh Patel
Phillip
Melanie Lynskey
June Mindy
Michael Chiklis
Dan Pawketty
Tomer Sisley
Adul Grelio
Paul Guilfoyle
General Themes
Robert Joy
Congressman Tenant
Jack Alberts
Oliver
Ting
Win
Lance A. Williams
Daniel
Shimali de Silva
Nisha
Hettienne Park
Dr. Calder
Rafael Silva
Nasa Scientist
Lonnie Farmer
Old Aide #1
Homa Sarabi-Daunis
White House Office Worker
Barbara Douglass
Office Worker
Rena Maliszewski
Anchor Reporting On Colon
Erik Parillo
Sherriff Conlon
Robert Hurst Radochia
Evan Mindy
Conor Sweeney
Marshall Mindy
Ross Partridge
Keith Ollens
Richard Donelly
Old Aide #2
Liev Schreiber
Bash Narrator (voice)
Samsara Yett
Isherwell Child Aide
Meara Mahoney Gross
Isherwell Child Aide
Jaden Onwuakor
Isherwell Child Aide
Staci Roberts
Linda Dicalio
Wendy Bellevue
Isherwell Child Handler
Mishka Yarovoy
Executive
Chris Everett
Chief Editor Paula Woods
Annette Miller
Mrs. Tanken
Stephen Thorne
Benjamin
Aimee Doherty
Passerby
Natalie Rebenkoff
Talent PA
Gary Tanguay
News Anchor #2
Georgia Lyman
Groomer Thalia
Patricia DeHaney
Hair Person
Ben Sidell
Stage Manager
Therese Plaehn
Autopsy Editor In Charge
Omar Ghonim
Damian
Jody O'Neil
Stage Manager #2
Meghan Leathers
Media Quant
Ashleigh Banfield
Dalia Hensfield
Sarah Silverman
Sarah Benterman
Richard Snee
Senator Lerner
Darryl Wooten
FBI Agent
Danielle Waxman
College Girl
Jeffrey Smith
Blind Man FBI Agent
Jon Glaser
Meow Man
Dorothy Dwyer
Old Tough Lady
Odis Spencer
Chief Justice
Sarah Nolen
Sammy Puppeteer
Alvin Keith
Harrison Telms
Alaina Pinto
American Reporter
Lizzie Short
French Reporter
Juri Love
Japanese Reporter
Sujoy De
Hindi Reporter
Brahms Guignard
Haitian Reporter
Sergei Bushmanov
Russian Reporter
Lewis D. Wheeler
Mission Coordinator
Steve Gagliastro
Onlooker
David J. Curtis
Guy
Kevin Craig West
Secretary of State
Alison Weller
Secretary of Education
Rob Lévesque
Secretary of Interior
Sam Zephir
Captain
Dee Nelson
Dr. Lisa Inez
Beau Allen
Dr. Talcamont
Rebecca Gibel
Waitress
Brian Faherty
Guy from the Bar
Celeste Oliva
Nearby Diner
Amanda Cass
Rioting Patron
Roman Mitichyan
Rioting Patron
Paul Marini
Rioting Patron
Alex Huynh
Rioting Patron
Michael Jibrin
Federal Agent
Bill Mootos
Federal Attorney
Patti Tippo
French President
Allyn Burrows
Mr. Dibiasky
Tori Davis Lawlor
Mrs. Dibiasky
Joy Lang
Housewife
June Holmes
Girl in Commercial
Graham Holmes
Boy in Commercial
Jacob Sanditen
Yule's Friend
Anthony Marrese
Other Friend
Caroline Bergwall
Teen Girl Friend
Anania Williams
Short Guy Friend
Nate Richman
Stocky FBI Agent
Wes Johnson
Don't Look Up'er
John Bucy
Don't Look Up'er
Patrick Gover
Don't Look Up'er
Conrad Perry
Don't Look Up'er
Matt Rouillard
Don't Look Up'er
Christopher Deschenes
Don't Look Up'er
Patrick Michael Strange
Just Look Up'er
J.P. Aaron
Just Look Up'er
Daniela August
Just Look Up'er
Nicholai Senat
Puppet Show Kid
Alexandra Zilch
Puppet Show Kid
Jonathan Kobs
Truthslinger303
Bianca de la Garza
Entertainment Journalist
Caitlin Ishibashi
DJ at Concert
Claire Davis
Bass Player
Elder Isaiah Perez
Organ Player
Coran Spardakis Henley
Drummer
Lance Norris
Loyal Supporter
Ralph M. Studley
Kid Rock Body Double
Frank Ridley
Flight Director
Andrew Haserlat
Mission Tech
Jayne McLendon
Command Tech
Ishaan Khatter
Raghav Manavalan
Khaldoun Rajeh
Egyptian Family
Sheren Rajeh
Egyptian Family
Khaled Rajeh
Egyptian Family
Kareem Rajeh
Egyptian Family
Ahmad Rajeh
Egyptian Family
Adila Rajeh
Egyptian Family
J.T. Turner
Old Billionaire
Ed Peed
Lobbyist
Zach Holmes
#LaunchChallenge MeTuber (uncredited)
Chris Evans
Devin Peters (uncredited)
Marissa Carpio
Reporter with Big Hair (uncredited)
Luan Gallagher
Boy looking at the meteor. (Uncredited)