John Barrymore
Don Jose de Marana / Don Juan de Marana
Jane Winton
Donna Isobel
John Roche
Leandro
Warner Oland
Cesare Borgia
Estelle Taylor
Lucrezia Borgia
Montagu Love
Count Giano Donati
Josef Swickard
Duke Della Varnese
Willard Louis
Pedrillo
Nigel De Brulier
Marchese Rinaldo
Hedda Hopper
Marchesia Rinaldo
Myrna Loy
Mai - Lady in Waiting
Mary Astor
Adriana della Varnese
Lionel Braham
Duke Margoni (uncredited)
Helene Costello
Rena - Adriana's Maid (uncredited)
Helena D'Algy
Donna Elvira (uncredited)
Jacob Dance
Gentleman (uncredited)
Yvonne Day
Don Juan - at age 5 (uncredited)
Philippe De Lacy
Don Juan - at age 10 (uncredited)
Emily Fitzroy
The Dowager (uncredited)
John George
Hunchback (uncredited)
Gibson Gowland
Gentleman of Rome (uncredited)
Phyllis Haver
Imperia (uncredited)
Sheldon Lewis
Gentleman of Rome (uncredited)
June Marlowe
Trusia (uncredited)
Dick Sutherland
Gentleman of Rome (uncredited)
Gustav von Seyffertitz
Neri - the Alchemist (uncredited)
Helen Lee Worthing
Eleanora (uncredited)