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Daniel Radcliffe
'Weird Al' Yankovic
Evan Rachel Wood
Madonna
Rainn Wilson
Dr. Demento
Toby Huss
Nick Yankovic
Jack Lancaster
Jim
Spencer Treat Clark
Steve
Tommy O'Brien
Bermuda
Arturo Castro
Pablo Escobar
Julianne Nicholson
Mary Yankovic
Diedrich Bader
Grizzled Narrator (voice)
Lin-Manuel Miranda
Doctor
Richard Aaron Anderson
Young Al
Thomas Lennon
Salesman
David Bloom
Teenage Al
Keanush Tafreshi
Kip
Andrew Steven Hernandez
Robbie
Paloma Esparza Rabinov
Hipster Teen
Scott Aukerman
Police Officer
Johnny Pemberton
Johnny Barf
Jonah Ray
Jonah Barf
Jeremy Bolm
Jeremy Barf
Eric Appel
Captain Buffoon
'Weird Al' Yankovic
Tony Scotti
Will Forte
Ben Scotti
Patton Oswalt
Heckler
Michael McKean
Sleazy MC
Dot-Marie Jones
Mama Bear
Dean Sharpe
Bartender
Jorma Taccone
Pee-Wee Herman
Demetri Martin
Tiny Tim
Paul F. Tompkins
Gallagher
Akiva Schaffer
Alice Cooper
Conan O'Brien
Andy Warhol
Emo Philips
Salvador Dali
Nina West
Divine
Jack Black
Wolfman Jack
David Dastmalchian
John Deacon
Anthony N.
Security Guard
Quinta Brunson
Oprah Winfrey
Julie Chang
Connie Chung
Josh Groban
Waiter
Seth Green
Radio DJ (voice)
Constantine Rousouli
Cone-Bra Dancer #1
James Brown III
Cone-Bra Dancer #2
Rocky Abou-Sakher
Terrorist Diner Patron
Chris Ryan
Kidnapper
Mike Escamilla
Guard #1
Chad Guerrero
Guard #2
Cesar Ramirez
Mariachi Band Member #1
Omar Estrada
Mariachi Band Member #2
Cesar Chavira
Mariachi Band Member #3
Jimmy Walker Jr.
Floor Manager
Trenyce
Diana Ross
James Preston Rogers
Hulk Hogan
William Guirola
Sicario
Paul Riley Fox
Elton John (uncredited)
Gordon Tarpley
David Bowie (uncredited)
Lisa Margaroli
Elvira, Mistress of the Dark (uncredited)
Erin O'Shea
Kate Pierson (uncredited)
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