Ed Helms
Rusty Griswold
Christina Applegate
Debbie Griswold
Skyler Gisondo
James Griswold
Steele Stebbins
Kevin Griswold
Chris Hemsworth
Stone Crandall
Leslie Mann
Audrey Griswold
Chevy Chase
Clark Griswold
Beverly D'Angelo
Ellen Griswold
Charlie Day
Chad
Catherine Missal
Adena
Ron Livingston
Ethan
Norman Reedus
Trucker
Keegan-Michael Key
Jack Peterson
Regina Hall
Nancy Peterson
Emyri Crutchfield
Sheila Peterson
Alkoya Brunson
Gary Peterson
Nick Kroll
Colorado Cop
Tim Heidecker
Utah Cop
Kaitlin Olson
Arizona Cop
Michael Peña
New Mexico Cop
Hannah Jeter
Ferrari Girl
David Clennon
Harry Co-Pilot
Colin Hanks
Jake
Kirstin Ford
Mom on Plane
Ethan Maher
Boy on Plane
Elizabeth Gillies
Heather
Cristina Squyres
Brooke
Nadine Avola
Chelsea
Ryan Cartwright
Terry
Valerie Payton
Shuttle Driver
O'Clair Alexander
Husky Lady at Monument
Miles Doleac
Man on the Monument
Holly Gardner
Women at Monument
R.F. Daley
Furious Husband
Elizabeth Fendrick
Furious Wife
Michael H. Cole
Male Guest
Brooke Jaye Taylor
Female Guest
Matthew Cornwell
Male Guest #2
Mitchell Warren
Wally World Kid #2
John Francis Daley
Ride Operator
Brandon Michael Hale
Gas Station Clerk (uncredited)
Libby Blake
Boobs (uncredited)
Rick Ericson
Hawaiian (uncredited)
Omar Lagudali
Reporter (uncredited)
Cameron McIntyre
Young James (age 7 / 9) (uncredited)
Jonathan Goldstein
Hot Tub Guy (uncredited)
John C. McGinley
Motorbike Cop