Charlie Tahan
Victor Frankenstein (voice)
Catherine O'Hara
Mrs. Frankenstein / Weird Girl / Gym Teacher (voice)
Martin Short
Mr. Frankenstein / Mr. Burgemeister / Nassor (voice)
Martin Landau
Mr. Rzykruski (voice)
Atticus Shaffer
Edgar "E" Gore (voice)
Winona Ryder
Elsa Van Helsing (voice)
Robert Capron
Bob (voice)
James Hiroyuki Liao
Toshiaki (voice)
Conchata Ferrell
Bob's Mom (voice)
Tom Kenny
New Holland Townsfolk (voice)
Frank Welker
Sparky Frankenstein (voice)
Dee Bradley Baker
Persephone van Helsing / Shelly / Were-Rat / Colossus
Jeff Bennett
Giant Sea Monkeys (voice)
Christopher Lee
Movie Dracula (archive footage)