Gabourey Sidibe
Claireece "Precious" Jones
Mo'Nique
Mary Lee Johnston
Paula Patton
Blu Rain
Mariah Carey
Mrs. Weiss
Lenny Kravitz
John McFadden
Sherri Shepherd
Lisa Cornrows
Stephanie Andujar
Rita Romero
Chyna Layne
Rhonda Patrice Johnson
Amina Robinson
Jermaine
Xosha Roquemore
Joann
Angelic Zambrana
Consuelo
Aunt Dot
Tootsie
Nealla Gordon
Mrs. Lichtenstien
Grace Hightower
Social Worker
Barret Helms
Tom Cruise (as Barret Isaiah Mindell)
Kimberly Russell
Katherine
Bill Sage
Mr. Wicher
Susan Taylor
Fairy Godmother
Kendall Toombs
Abdul, New Born
Alexander Toombs
Abdul, New Born
Cory Davis
Abdul, 9 Months
Rochelle McNaughton
AIDS Clerk
Abigail Savage
Bunny